brain damage — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9232	Mitochondrial fusion promoter M1		Mitochondrial Metabolism
	Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia...		Mitochondrial Metabolism
T21793	CGP 35348		GABA Receptor
	CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.		GABA Receptor
T9776	TRPM4 inhibitor 8		TRP/TRPV Channel
	TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.		TRP/TRPV Channel
T70470L	Isomer-CM 352	isomer-1542205-83-3	MMP
	isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.		MMP
T4S1725	Galanthamine	Galantamine	Apoptosis , AChE
	Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.		Apoptosis , AChE
T28607	Rocepafant	LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation
	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor...		Platelet aggregation
T70470	CM-352		MMP
	CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.		MMP
T3414	Morroniside		Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...		Apoptosis , MMP , Pyroptosis
T5S0636	Citric acid	Citro,Citretten	Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic
	1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili...
T32098L	Homocarnosine acetate		GABA Receptor , Endogenous Metabolite
	Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition o...		GABA Receptor , Endogenous Metabolite
T73599	TSPO ligand-1		Autophagy
	TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autop...		Autophagy
T3S1729	Dihydrolycorine		Others
	1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inh...		Others
T5232	3-Methyl-2-oxobutanoic acid	2-Oxoisovaleric acid,alpha-Ketoisovaleric acid	Others , Endogenous Metabolite
	3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 3-Methyl-2-oxobutanoic acid is a neurotoxin, an acidogen, and a metabo...		Others , Endogenous Metabolite
T72662	NMDAR/TRPM4-IN-2		ERK , TRP/TRPV Channel , NMDAR , iGluR
	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot...		ERK , TRP/TRPV Channel , NMDAR , iGluR
T38063	N-Acetyl lysyltyrosylcysteine amide		Glutathione Peroxidase
	N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Ac...		Glutathione Peroxidase
T61268	Vutiglabridin	HSG4112	Phosphatase
	Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stabilit...		Phosphatase
T25722	Lifarizine methanesulfonate
	Lifarizine methanesulfonate is a modulator of sodium-calcium channel that reduces ischemic brain damage.
T27959	LY503430	LY-503430,LY 503430
	LY503430 is a AMPA receptor potentiator with oral activity. LY503430 has both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP.
T70838	RO27-3225 TFA
	RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225...
T26627	Anatibant	LF16-0687,LF-16-0687,LF 160687,LF 16-0687,LF-160687
	Anatibant is a potent non-peptide bradykinin B2 receptor antagonist. Anatibant reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury.